Nicole Kleinstreuer (ILS, Inc./NICEATM)

Another successful “AOPs 101″ session

Anne Gourlemon (OECD)

Anne Gourlemon (OECD)

On Sunday, August 24 – just ahead of the 9th World Congress on Alternatives and Animal Use in the Life Sciences (“WC9″) in Prague – the HTPC and Physicians Committee for Responsible Medicine (PCRM) co-sponsored an “AOPs 101″ session.  Like the sessions offered at SOT earlier this year, this one was designed to introduce the Adverse Outcome Pathway concept to scientists who want to learn more about it, including how to apply it in their own work.

The session opened with an overview and introduction by Catherine Willett (HTPC).  Anne Gourmelon presented on the OECD’s AOP program.  Kristie Sullivan (PCRM) gave an introduction to the AOP Wiki, and Hristo Aladjov (OECD) introduced Effectopedia.  These overview talks were followed by two case study presentations: Joanna Jaworska (Procter & Gamble) described the use of AOPs in a Bayesian network ITS framework to assess skin sensitization, and Nicole Kleinstreuer (ILS, Inc./NICEATM) described the construction of AOPs for developmental toxicities.  The talks generated excellent follow-up questions and discussion.

Nicole Kleinstreuer (ILS, Inc./NICEATM)

Nicole Kleinstreuer (ILS, Inc./NICEATM)

Kristie Sullivan (PCRM)

Kristie Sullivan (PCRM)

9th World Congress on Alternatives AOPs Meetings & Events

AOP workshop in Prague

At the 9th World Congress on Alternatives and Animal Use in the Life Sciences, the HTPC – along with Physicians Committee for Responsible Medicine (PCRM) – will co-sponsor an introductory workshop on Adverse Outcome Pathways, “AOPs 101: The How and Why of Development and Use,” on August 24, 2014 from 10 AM to 12 PM at Riverdance + Hibernia Conference Halls, Jurys Inn (next to the WC9 venue).

The curriculum will compliment several presentations on AOPs at the World Congress, and is intended for those scientists who are not yet familiar with the AOP concept but would like to learn to apply it to their own work, or would like to become involved in ongoing projects. An overview of “what, why, and how” will be given according to the latest existing international guidance, and experts will present case studies demonstrating AOP development and application.

A draft agenda is available here.

9th World Congress on Alternatives AOPs Meetings & Events slideshow

AOP chapter in newly published “Encyclopedia of Toxicology”

AOP diagram“Adverse Outcome Pathways: Development and Use in Toxicology,” a chapter in Elsevier’s Encyclopedia of Toxicology (3rd edition) written by HSUS/HTPC’s Dr. Catherine Willett, introduces readers to the concept of Adverse Outcome Pathways (AOP) and explains how they can improve the efficiency and accuracy of toxicity testing while reducing the use of animals.  Dr. Willett’s chapter discusses how to construct an AOP, explores possible regulatory uses, and includes descriptions of two AOPs currently under development by the international research community.

AOPs Publications

Successful “AOPs 101″ ancillary workshop at SOT 2014

AOPs 101: the How and Why of Development and Use,” the ancillary program co-sponsored and organized by HTPC and ASCCT, was a perfect fit for this year’s SOT conference.  With an unprecedented number of Adverse Outcome Pathway (AOP)-related sessions and symposia on the 2014 Scientific Program, the workshop’s aim to introduce AOP fundamentals to scientists not yet familiar with the concept was successful: the 60 or so attendees asked many insightful questions and were clearly appreciative in comments following the presentations.  Program presentations covering the fundamentals of AOP construction and potential applications, as well as summaries of three case studies of AOPs currently or recently under development, are available below:

Kristie Sullivan – What are AOPs?

Catherine Willett – Why are AOPs important, and how can they be useful?

Terry Schultz – AOPs: Getting Started

Nicole Kleinstreuer – Constructing AOPs for Developmental Toxicities

Grace Patlewicz – Development of an AOP for Skin Sensitization and Practical Applications (slides here)

Mathieu Vinkin – Development and Use of Hepatic AOPs in the SEURAT Project Cluster

AOPs Meetings & Events

HTPC liver toxicity workshop proceedings published in ALTEX, “Online First”

Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology:Liver Toxicity Mode-of-Action,” a report summarizing a workshop coordinated by HTPC in 2013, and co-authored by workshop participants, has been published by ALTEX in “Online First.”  From the summary:

A workshop sponsored by the Human Toxicology Project Consortium (HTPC), “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action”brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is extremely helpful. In addition, it is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered.


AOPs Meetings & Events Publications

“Advancing AOPs for Integrated Toxicology and Regulatory Applications”

kw talk slide 1Human Toxicology Project Consortium Coordinator Catherine Willett was in Italy last week to take part in “Advancing AOPs for Integrated Toxicology and Regulatory Applications.”  Co-sponsored by a broad range of stakeholders*  and organized by the European Commission, US Army Corps and US EPA, this workshop was designed to build on the advancements of two previous workshops, “A Vision and Strategy for Predictive Ecotoxicology in the 21st Century: Defining Adverse Outcome Pathways Associated with Ecological Risk” (SETAC Pellston, Forest Grove, OR, 2009) and “Development of alternatives to chronic ecotoxicity tests: predicting early life stage and endocrine-mediated toxicity in aquatic vertebrate species” (ILSI-HESI, Paris, France, 2010).  Like the previous workshops, this one brought together dozens of scientists representing industry, academia, government, and non-governmental organizations from around the world.  The goal was for participants to develop specific approaches for the regulatory application of AOPs, focusing on how to use AOPs to understand and reduce uncertainties in the risk assessment process, and to support Informed Approaches to Testing and Assessment.

Workshop organizers anticipate that the discussions will form the basis for symposia at the upcoming SETAC Europe 24th Annual Meeting (May 2014) and SETAC North America 35th Annual Meeting (November 2014), and will also generate one or more open access journal articles.

Update: The slides for Dr. Willett’s presentation, “Animal Welfare Perspective on Pathway-based Approaches to Safety Assessment,” can be downloaded here (PDF).

*Co-sponsors included Environment Canada, Humane Society of the United States, United States Environmental Protection Agency, ILSI-HESI, BioDetection, European Commission – Joint Research Centre, Norwegian Institute for Water Research (NIVA), US Army Engineer Research and Development Center (ERDC), European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), American Chemistry Council, and Italian – Regional EPA.

AOPs Meetings & Events