chemistry

New Chemical Lists Information System (CheLIST)

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) released a new search tool, the Chemical Lists Information System (CheLIST), to help researchers determine if a chemical has ever been used in a research or validation study.  To develop and validate new non-animal alternative toxicity tests, researchers need to test a method’s performance with “reference” chemicals, or group of chemicals that have already been well-characterized.  The availability of extensive libraries of such reference chemicals – thoroughly characterized and tested – can speed up the development of non-animal toxicity test methods by providing many benchmarks against which the method’s findings can be compared.  There is undoubtedly a wealth of such chemical information scattered throughout published scientific literature and in various public and private databases, but these sources are difficult and time-consuming for researchers to access and interpret.  CheLIST is the EURL ECVAM’s first effort to consolidate chemical information in a central database with a user-friendly interface.  A Joint Research Centre (JRC) announcement describes CheList as being “in its infancy” at present, but notes that it will grow as its developers continue to search for and curate content.  To learn more about CheList, see the JRC’s announcement, or explore the database here.

databases toxicity testing alternatives