Nicole Kleinstreuer (ILS, Inc./NICEATM)

Another successful “AOPs 101″ session

Anne Gourlemon (OECD)

Anne Gourlemon (OECD)

On Sunday, August 24 – just ahead of the 9th World Congress on Alternatives and Animal Use in the Life Sciences (“WC9″) in Prague – the HTPC and Physicians Committee for Responsible Medicine (PCRM) co-sponsored an “AOPs 101″ session.  Like the sessions offered at SOT earlier this year, this one was designed to introduce the Adverse Outcome Pathway concept to scientists who want to learn more about it, including how to apply it in their own work.

The session opened with an overview and introduction by Catherine Willett (HTPC).  Anne Gourmelon presented on the OECD’s AOP program.  Kristie Sullivan (PCRM) gave an introduction to the AOP Wiki, and Hristo Aladjov (OECD) introduced Effectopedia.  These overview talks were followed by two case study presentations: Joanna Jaworska (Procter & Gamble) described the use of AOPs in a Bayesian network ITS framework to assess skin sensitization, and Nicole Kleinstreuer (ILS, Inc./NICEATM) described the construction of AOPs for developmental toxicities.  The talks generated excellent follow-up questions and discussion.

Nicole Kleinstreuer (ILS, Inc./NICEATM)

Nicole Kleinstreuer (ILS, Inc./NICEATM)

Kristie Sullivan (PCRM)

Kristie Sullivan (PCRM)

9th World Congress on Alternatives AOPs Meetings & Events
Stare-Mesto-Prague-creative-commons-e1383206240634

AOP workshop in Prague

At the 9th World Congress on Alternatives and Animal Use in the Life Sciences, the HTPC – along with Physicians Committee for Responsible Medicine (PCRM) – will co-sponsor an introductory workshop on Adverse Outcome Pathways, “AOPs 101: The How and Why of Development and Use,” on August 24, 2014 from 10 AM to 12 PM at Riverdance + Hibernia Conference Halls, Jurys Inn (next to the WC9 venue).

The curriculum will compliment several presentations on AOPs at the World Congress, and is intended for those scientists who are not yet familiar with the AOP concept but would like to learn to apply it to their own work, or would like to become involved in ongoing projects. An overview of “what, why, and how” will be given according to the latest existing international guidance, and experts will present case studies demonstrating AOP development and application.

A draft agenda is available here.

9th World Congress on Alternatives AOPs Meetings & Events slideshow
guineapg

HTPC co-sponsors training in non-animal cosmetics testing

HTPC is co-sponsoring an important training program coordinated by the Institute for In Vitro Sciences (IIVS) and Humane Society International (HSI), to introduce Chinese scientists and regulators to non-animal methods for cosmetics testing.  As part of the program, scientists will receive hands-on training in state-of-the-art in vitro methods that replace traditional tests on rabbits and guinea pigs.

Organized through China’s Guangdong Inspection and Quarantine Bureau, HSI and the IIVS’s training aims to help fill this knowledge gap, making the option to move away from animal testing a practical alternative. China’s consumer and science sectors have much to gain from such a transition – animal toxicity tests are some of the least scientifically credible methods still in use. Indeed, when you consider the scale of uncertainty associated with some of these approaches, it’s astonishing that in so many countries and across so many sectors we’re still gambling consumer safety on methods that were devised in the 1940s.

Read more about the program in this article by Troy Seidle (HSI).

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SatelliteRoom

Enthusiastic turnout for CAAT/HTPC satellite meeting at SOT 2014

 

Getting exhausted participants to attend a satellite meeting at the end of the three-and-a-half-day ultra-marathon that is a Society of Toxicology annual meeting would seem to be a tough sell.  But nearly 80 turned out for the CAAT/HTPC meeting, “Updates on 21st Century Toxicology Activities and Related Efforts” in Phoenix, AZ.  Thomas Hartung (CAAT) welcomed attendees, and gave a brief history of this now-annual event, and outlined the afternoon’s agenda.  Updates on specific programs and activities were provided by David Dix (various EPA programs), Rusty Thomas (Toxcast), Alex Merrick (Tox21), Mel Anderson (The Hamner Institute’s efforts), Mark Cronin (SEURAT-1), Thomas Hartung (CAAT’s Human Toxome project), Kate Willett  (HTPC and HSUS activities), and Martin Stephens (CAAT’s Evidence-Based Toxicology Consortium activities).  At the end of the invited presentations, the floor was opened to questions, discussions, and brief updates on relevant projects or activities from those in attendance.  The enthusiastic turnout demonstrates that interest and participation in the 21st century “paradigm shift” in toxicology continues to grow.

Meetings & Events

Successful “AOPs 101″ ancillary workshop at SOT 2014

AOPs 101: the How and Why of Development and Use,” the ancillary program co-sponsored and organized by HTPC and ASCCT, was a perfect fit for this year’s SOT conference.  With an unprecedented number of Adverse Outcome Pathway (AOP)-related sessions and symposia on the 2014 Scientific Program, the workshop’s aim to introduce AOP fundamentals to scientists not yet familiar with the concept was successful: the 60 or so attendees asked many insightful questions and were clearly appreciative in comments following the presentations.  Program presentations covering the fundamentals of AOP construction and potential applications, as well as summaries of three case studies of AOPs currently or recently under development, are available below:

Kristie Sullivan – What are AOPs?

Catherine Willett – Why are AOPs important, and how can they be useful?

Terry Schultz – AOPs: Getting Started

Nicole Kleinstreuer – Constructing AOPs for Developmental Toxicities

Grace Patlewicz – Development of an AOP for Skin Sensitization and Practical Applications (slides here)

Mathieu Vinkin – Development and Use of Hepatic AOPs in the SEURAT Project Cluster

AOPs Meetings & Events

HTPC liver toxicity workshop proceedings published in ALTEX, “Online First”

Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology:Liver Toxicity Mode-of-Action,” a report summarizing a workshop coordinated by HTPC in 2013, and co-authored by workshop participants, has been published by ALTEX in “Online First.”  From the summary:

A workshop sponsored by the Human Toxicology Project Consortium (HTPC), “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology: Liver Toxicity Mode-of-Action”brought together experts from a wide range of perspectives to inform the process of pathway development and to advance two prototype pathways initially developed by the European Commission Joint Research Center (JRC): liver-specific fibrosis and steatosis. The first half of the workshop focused on the theory and practice of pathway development; the second on liver disease and the two prototype pathways. Participants agreed pathway development is extremely useful for organizing information and found that focusing the theoretical discussion on a specific AOP is extremely helpful. In addition, it is important to include several perspectives during pathway development, including information specialists, pathologists, human health and environmental risk assessors, and chemical and product manufacturers, to ensure the biology is well captured and end use is considered.

 

AOPs Meetings & Events Publications