The Science

 

Publications:

Willett, C., Caverly Rae, J., Goyak, K.O., et al. “Building Shared Experience to Advance Practical Application of Pathway-Based Toxicology.” ALTEX (Online First), doi: http://dx.doi.org/10.14573/altex.1401281

Bishop P. and Willett C. (2013). “The Use and Acceptance of Other Scientifically Relevant Information (OSRI) in the US EPA Endocrine Disruptor Screening Program.” Birth Defects Research, Part B: Developmental and Reproductive Toxicology. Published online: 22 OCT 2013, DOI: 10.1002/bdrb.21077 (Summary here.)

Jacobs M.N., Laws S.C., Willett K., Schmieder P., Odum J., Bovee T.F. (2013). “In vitro metabolism and bioavailability tests for endocrine active substances: What is needed next for regulatory purposes?” ALTEX 30(3):331-51.

Vinken M., Landesmann B., Goumenou M., Vinken S., Shah I., Jaeschke H., Willett C., Whelan M., Rogiers V. (2013). “Development of an adverse outcome pathway from drug-mediated bile salt export pump inhibition to cholestatic liver injury.” Toxicological Sciences: published online August 14, 2013 doi:10.1093/toxsci/kft177

Willett, C. (2012). Tox21C: The AOP Approach Applied to REACH axlr8-progress-report-2012, in Alternative Testing Strategies: Progress Report 2012 & AXLR8-3 Workshop Report on a ‘Roadmap to Next Generation Safety Testing Under Horizon 2020,’ eds. Troy Seidle and Horst Spielmann, AXLR8 Consortium.  (Also presented at the AXLR8 Workshop, 10 June 2012, Berlin Germany.)

Stephens, M.L., et al. (2012). Accelerating the Development of 21st-Century Toxicology: Outcome of a Human Toxicology Project Consortium Workshop. Toxicological Sciences 125(2): 327-334.

Presentations:

Willett, C. (2014). Animal Welfare Perspectives on Pathway-based Approaches to Safety Assessment. Presented at ‘Advancing AOPs for Regulatory Applications,’ March 2-7, 2014, Somma Lombardo, Italy.

Willett, C. (2013). Pathway-based Approaches to Safety Assessment: Development and Use. Poster presented at the 2nd Annual Meeting of the American Society for Cellular & Computational Toxicology, October 31, 2013, Bethesda, MD.

Matevia, M., Willett, C. (2013). The Human Toxicology Project Consortium: Advancing a New Paradigm for Assessing Chemical Safety. Poster presented at the 2nd Annual Meeting of the American Society for Cellular & Computational Toxicology, October 31, 2013, Bethesda, MD.

Willett, C. (2013). Pathway-based Approaches to Safety Assessment: Development and Use. Presented at the IVTIP Spring 2013 Meeting ’2013: State of the art on alternatives from an industrial point of view: ready for regulation?’ May 15-16, 2013, Southampton, UK.

Willett, C. (2013).  The Future of Endocrine Screening: An Animal Welfare Perspective. Presented at Lessons Learned, Challenges, and Opportunities: The US Endocrine Disruptor Screening Program, April 23-24, 2013, North Carolina Biotechnology Center, Research Triangle Park, North Carolina.

Willett, C. (2012). Evolving Approaches to AOP Development: Observations from MOA Frameworks to Systems Biology. Presented at the SEURAT-1 Workshop: Liver Toxicity Adverse Outcome Pathways, 25-26 October 2012, Ispra, Italy.

 

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2010 Human Toxicology Project Consortium Symposium Presentations