Human Toxicology Project Consortium Coordinator Catherine Willett was in Italy last week to take part in “Advancing AOPs for Integrated Toxicology and Regulatory Applications.” Co-sponsored by a broad range of stakeholders* and organized by the European Commission, US Army Corps and US EPA, this workshop was designed to build on the advancements of two previous workshops, “A Vision and Strategy for Predictive Ecotoxicology in the 21st Century: Defining Adverse Outcome Pathways Associated with Ecological Risk” (SETAC Pellston, Forest Grove, OR, 2009) and “Development of alternatives to chronic ecotoxicity tests: predicting early life stage and endocrine-mediated toxicity in aquatic vertebrate species” (ILSI-HESI, Paris, France, 2010). Like the previous workshops, this one brought together dozens of scientists representing industry, academia, government, and non-governmental organizations from around the world. The goal was for participants to develop specific approaches for the regulatory application of AOPs, focusing on how to use AOPs to understand and reduce uncertainties in the risk assessment process, and to support Informed Approaches to Testing and Assessment.
Workshop organizers anticipate that the discussions will form the basis for symposia at the upcoming SETAC Europe 24th Annual Meeting (May 2014) and SETAC North America 35th Annual Meeting (November 2014), and will also generate one or more open access journal articles.
Update: The slides for Dr. Willett’s presentation, “Animal Welfare Perspective on Pathway-based Approaches to Safety Assessment,” can be downloaded here (PDF).
*Co-sponsors included Environment Canada, Humane Society of the United States, United States Environmental Protection Agency, ILSI-HESI, BioDetection, European Commission – Joint Research Centre, Norwegian Institute for Water Research (NIVA), US Army Engineer Research and Development Center (ERDC), European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC), American Chemistry Council, and Italian – Regional EPA.