“AOPs 101: the How and Why of Development and Use,” the ancillary program co-sponsored and organized by HTPC and ASCCT, was a perfect fit for this year’s SOT conference. With an unprecedented number of Adverse Outcome Pathway (AOP)-related sessions and symposia on the 2014 Scientific Program, the workshop’s aim to introduce AOP fundamentals to scientists not yet familiar with the concept was successful: the 60 or so attendees asked many insightful questions and were clearly appreciative in comments following the presentations. Program presentations covering the fundamentals of AOP construction and potential applications, as well as summaries of three case studies of AOPs currently or recently under development, are available below:
Kristie Sullivan – What are AOPs?
Catherine Willett – Why are AOPs important, and how can they be useful?
Terry Schultz – AOPs: Getting Started
Nicole Kleinstreuer – Constructing AOPs for Developmental Toxicities
Grace Patlewicz – Development of an AOP for Skin Sensitization and Practical Applications (slides here)
Mathieu Vinkin – Development and Use of Hepatic AOPs in the SEURAT Project Cluster