You’ll find the Human Toxicology Project Consortium at the Society of Toxicology’s annual meeting in New Orleans next week – in the ToxExpo center, poster sessions, workshops, and seminars.

  • Visit HTPC’s informational booth at ToxExpo, booth #1704.
  • HTPC is co-sponsoring a “hands-on” seminar, “Creating an Adverse Outcome Pathway in the AOP Wiki,” on Tuesday, March 15, from 5-7PM in the Hilton Riverside.  More details about the seminar can be found here.
  • HTPC is also once again co-sponsoring and presenting at the annual SOT Satellite Meeting, Updates on Activities Related to 21st Century Toxicology and Related Efforts: Invited Presentations and Open Microphone, on Thursday, March 17, 12:30 PM to 4:00 PM, Hilton New Orleans Riverside, Jefferson Ballroom. As always, this informative meeting features a number of invited presentations, and also allows time for an “open microphone” segment in which participants are welcome to give brief presentations on germane topics.

The draft program is as follows:

12:30 PM—Box Lunch (for pre-registered participants) and Welcome by Thomas Hartung, Johns Hopkins University

1:00 PM—Invited Speakers (10 minute presentations each followed by 5 minute of discussion)

ToxCast Update: Russell Thomas, US Environmental Protection Agency

EDSP21 Update: David Dix, US Environmental Protection Agency

Tox21 Update: Richard Paules, US National Toxicology Program

Hamner TT21C Update: Melvin Andersen, Hamner Institutes

NICEATM Update: Warren Casey, NICEATM

SEURAT/EU Tox-Risk Update: Michael Schwarz, University of Tuebingen

CAAT’s Read-Across Initiative and Human Toxome-Related Activity Update: Thomas Hartung, Johns Hopkins

Human Toxicology Project Consortium Update: Catherine Willett, HTPC

Evidence-Based Toxicology Update: Martin Stephens, Johns Hopkins

3:15 PM—Open Microphone for Additional Presentations and Discussion

4:00 PM—Adjourn

  • Kate Willett will also present a poster in the Regulation and Policy session, Wednesday, March 16, 1:15 PM to 4:45 PM: “Regulatory Acceptance of Non-standard Toxicological Methods through Increased use of Integrated Approaches to Testing and Assessment (IATA)” (Abstract #3003/Poster #P143).

Corporate members and partners of HTPC will be presenting at SOT next week, as well.  Scientists from each of the member corporations are coauthors on the following posters:

(First number is the abstract #, second is the Poster Board #)

Dow
#1120, P149: Development of a Predictive Systems Toxicology Platform to Enhance Novel Molecule Design.

#1271, P420: Effects of Heavy Metals on Calcium Oxalate (CaOx) Crystal Formation in a Drosophila melanogaster Model of Nephrolithiasis.

#1881, P186: ToxCast Outcomes for Biphenyl Indicate Concordance with Recognized In Vivo Biological Effects.

#1891, P196: Integration of Relevant Carcinogenicity and Endocrine Data in a Systemic Approach Establishes the Mode of Action for Pronamide Induced Thyroid Tumors.

ExxonMobil

#2468, P534: Evaluating the Ability of High-Throughput Screening (HTS) Assays to Capture the Biological Activity of Industrial Chemicals.

#2648, P146: Development and Application of a Novel QSAR to Assess Potential Species Differences in Developmental Toxicity.

L’Oreal
#1113, P142: A Mechanism-Based Hepatotoxicity Simulation Model to Capture Dose-Dependent Cell Death Dynamics in Response to the Drugs Amiodarone and Valproate.

#1228, P325: Development of an In Vitro Neuromuscular Junction System Between Human Stem Cell-Derived Motoneurons and Human Skeletal Muscle to Evaluate Compound Toxicity.

#1612, P450: Assessment of the Predictive Capacity of SkinEthic™ HCE Human Corneal Test Method for Serious Eye Damage/Eye Irritation Assessment: A Depth Analysis Based on the Drivers of UN GHS Classification.

#1613, P451: Use of HPLC/UPLC-Spectrophotometry for Detection of Formazan in SkinEthic™ HCE Reconstructed Human Corneal Test Method to Expand Its Applicability to Strongly Coloured Chemicals.

#1614, P452: Intra- and Inter-Laboratory Evaluation of SkinEthic™  HCE Test Method on Solid and Liquid Chemicals for Serious Eye Damage/Eye Irritation Assessment.

#1616, P454: Critical Review of the UN GHS Decision Criteria for Chemicals Causing Irreversible Effects on the Eye/Serious Damage to the Eye: Cosmetics Europe Analysis.

#2007, P411: A Human Heart-Liver Platform to Study Drug Metabolism and Toxicity.

#2015, P419: Exploration of Drug-Induced Mitochondrial Toxicity Mechanisms on Hepatic Mitochondria and Cultured Cells.

#2182, P112: Development of a 3D In Vitro Model for the Assessment of Repeated Dose Hepatotoxicity.

#2206, P136: Applicability Domain of the U-SENS™ Test Method for Skin Sensitization Testing over 175 Chemicals.

#2477, P603: A Four-Organ-on-a-Chip Microfluidic System: Towards a Tool for Long-Term Systemic Toxicity Assessment.

#2625, P123: Predictive Model of Systemic Toxicity.

#2865, P516: Integrated Testing Strategy for Skin Sensitization Assessment.

#3512, P204: Partition and Diffusion Coefficient Determinations for Twelve Compounds in Isolated Human Skin Layers for In Silico Dermal Pen Modeling.

Procter & Gamble
#2475, P601: Final Report on the Development of Non-Cancer Threshold of Toxicological Concern (TTC) Database to Support Alternative Assessment Methods for Cosmetics-Related Chemicals.

#2925, P617: In Vitro Fish Hepatic Metabolism: A Ring-Trial to Evaluate Transferability, Intra- and Interlaboratory Reproducibility.

Unilever
#2174, P104: Assessment of Androgenic and Anti-Androgenic Activity Using RWPE-1 Prostate Microtissues.

#2183, P113: Molecular Initiating Events in Toxicity Pathways Using Organotypic Human In Vitro Models.

#2646, P144: Mechanistic Model-Based Approach to Skin Sensitisation Risk Assessment.

#3051, P203: Developing a Mitochondrial Toxicity Pathway-Based Framework for Chemical Safety Assessment: A Case Study of PGC-1α-Mediated Network Perturbation with Doxorubicin.

#3071, P223: Dose Response Studies Supporting In Vitro-Based Safety Assessments for Chemicals Inducing Oxidative Stress.

CAAT
#2632, P130: A Systematic Review of the Zebrafish Embryological Test as an Alternative to the Mammalian Developmental Test (OECD 414): A Pilot for an Evidence-Based Toxicology Approach.

#2340, P311: In Vitro Toxicity and Resilience of a 3D Human Dopaminergic Model to Rotenone.

#3265, P617: NTE Protein and Encoding Gene in Neurodevelopment and Neurodevelopmental Toxicity.

HESI
#2925, P617: In Vitro Fish Hepatic Metabolism: A Ring-Trial to Evaluate Transferability, Intra- and Interlaboratory Reproducibility.

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HTPC member scientists are also giving a number of talks in or co-chairing workshop sessions:

Dow
Workshop Session: Scientific Reproducibility: Does This Pose a Problem for 21st Century Toxicology?, Monday Morning, March 14, 9:30 AM to 12:15 PM, CC Great Hall A (co-chairs)

Platform Session: Investigating Mode of Action in Chemical Carcinogenesis, Monday Morning, March 14, 9:30 AM to 12:15 PM (co-chairs)

Symposium Session: The Promise and Reality of Alternative Methods in Inhalation Toxicology and the Development of Inhaled Therapeutics, Monday, March 14, 2:00 PM to 4:45 PM, CC Room R02:

  • #1706 2:35 In Silico Models to Predict Acute Inhalation Toxicity and Identify Potential Chemical Respiratory Sensitizers

Workshop Session: Using 21st Century Approaches to Evaluate Endocrine-Active Compounds Recent Advances in Safety Assessment, Monday, March 14, 2:00 PM to 4:45 PM, CC Great Hall A (co-chairs)

Workshop Session: Bioactivity-Based Margin of Exposure Safety Assessment: The Next Stop along the Road to 21st Century Safety Assessments, Tuesday, March 15, 9:30 AM to 12:15 PM, CC Great Hall B (co-chairs)

L’Oreal
Workshop Session: Paradigm Change in Toxicology: What Will It Take to Bring Advances in the Science of Toxicology into Regulatory Use? Wednesday, March 16, 9:30 AM to 12:15 PM, CC Room 208

  • #2577 11:20 Next Challenge for Cosmetic Industry in Europe: Systemic Toxicity Case Study

Procter & Gamble
Workshop Session: Advanced Techniques in PBPK Modeling to Improve Quantitative Risk Assessment for Infants and Children, Wednesday, March 16, 2:00 PM to 4:45 PM, CC Room 220

  • #3318, 2:34, Age-Specific PBPK Models

Workshop Session: Which Human Cell Lines Should I Use? Choosing the Appropriate Biological Systems for High-Throughput Toxicity Testing, Thursday, March 17, 9:30 AM to 12:15 PM, CC Room 217

  • #3384 10:12 Selecting Cell Types that Provide Transcriptomic Data Over a Broad Range of Modes of Action

ScitoVation
Continuing Education course, Molecular Toxicology: Mechanistic Insights and Hazard Assessment, Sunday, March 13, 1:15 PM–5:00 PM, CC Second Floor (co-chairs and presenters)

Melvin Andersen will give the Merit Award Lecture, Monday, March 14, 12:30 -1:20 PM (CC Room R08)

Unilever
Symposium Session: High-Content Imaging for Predictive Toxicology: Discriminating between Adverse and Adaptive Outcomes, Wednesday Afternoon, March 16, 2:00 PM to 4:45 PM, CC Room 208

  • #3305 4:05 Utilizing High-Content Imaging Tools Toward Pathways-Based Safety Assessments: A Consumer Product Industry Perspective

CAAT
Workshop Session: Scientific Reproducibility: Does This Pose a Problem for 21st Century Toxicology?, Monday, March 14, 9:30 AM to 12:15 PM, CC Great Hall A

  • #1037 10:35 Evidence-Based Approaches for Enhancing the Reproducibility of Toxicological Studies

Workshop Session: Read-Across: Building Scientific Confidence in the Development and Evaluation of Read-Across for Regulatory Purposes Using Tox21 Approaches, Tuesday, March 15, 2:00 PM to 4:45 PM, CC Room 220

  • #2529 3:45 CAAT and the Work of the Read-Across Steering Group