This online course is intended for researchers and risk and hazard assessors from a broad array of government, public, and private sectors who have an interest in submitting or using AOPs, or who are generating data that can be used to develop AOPs.

The course is designed to:
• Be a freely accessible, consolidated, centralized repository of current and core AOP training materials and resources;
• Increase the number and quality of vetted AOPs available for advanced research on network perturbations as well as regulatory
decision making;
• Provide an overview as well as detailed tutorials on how to create and evaluate AOPs using the AOP Wiki; and
• Support progress towards achieving the goals of the 3Rs – Replace/Reduce/Refine the use of animals in laboratory testing and education.
Learn more about the course (PDF file) >>

The first course module explores the history and importance of the pathway approach, the OECD AOP Programme, general principles on the development and use of AOPs, and the quality criteria used to evaluate AOPs. This module can be included in a graduate or advanced undergraduate curriculum. Additional AOP-KB tools currently under development (Effectopedia, AOP Xplorer and Intermediate Effects Database) are also discussed.
Download the first course module to run on your computer (zip file) >>
Download the first module to run in your browser (zip file) >>

The second course module provides detailed step-by-step instruction on the information needed to develop and submit quality AOPs to the AOP-Wiki site.
Download the second course module to run on your computer (zip file) >>
Download the second course module to run in your browser (zip file) >>

To view a module in your browser (PC or Mac): Download the corresponding zip file to your computer. Once the folder has successfully downloaded, right click on the folder and select “Extract All…” Once the files have been extracted, double-click on the folder to open it; then double-click on the “story.html” or the “story_html5.html” file to launch the course in Chrome, Firefox, Safari, or Internet Explorer.

To view a module on your computer (PC only): Download the corresponding zip file to your computer. Once the folder has successfully downloaded, right click on the folder and select “Extract All…” Once the files have been extracted, double-click on the folder to open it; then double-click on the “Launch_Story.exe” file to launch the course.

Questions/suggestions: Please contact Kate Willett at kwillett@humanesociety.org.