Emerging Technology Toward Pathway-Based Human Brain Research
May 29-30, 2017
D’Or Institute for Research and Education
Rio de Janeiro, Brazil

Monday, 29 May 2017
12.00 – 13.30 Welcome lunch
13.30 – 13.40 Welcome by Marcia Triunfol (HSI Brazil Science Advisor)
13.40 – 14.00 Toward a human pathway paradigm in health research
Troy Seidle, HSI Director of Research & Toxicology
14.00 – 14.30 Organoids: A historical perspective of thinking in three dimensions
Marina Simian, Instituto de Nanosistemas, Universidad Nacional de San
Martín, Argentina
14.30 – 15.00 New insights about the biology of zika virus infection using iPS cells
Stevens Rehen, Institute D’Or and Universidade Federal do Rio de
Janeiro, Brazil
15.00 – 15.30 Mini-brains to study Dravet disease
Fabio Klamt, Universidade Federal do Rio Grande do Sul, Brazil
15.30 – 16.00 Coffee break
16.00 – 16.30 A human brain microphysiological system derived from iPSC to study
neurological diseases, toxicity and infection diseases
David Pamies, Johns Hopkins University, USA
16.30 – 17.00 Modeling autism spectrum disorders with human neurons
Patricia Brandão, University of São Paulo, Brazil
Cocktail / Dinner (time and place to be announced)

Tuesday, 30 May 2017
09.00 – 09.30 Breakfast
09.30 – 10.00 The promises and challenges of human brain organoids as models of
neuropsychiatric diseases
Georgia Quadrato, Harvard Stem Cell Institute, USA
10.00 – 10.30 Human iPS-derived motor neurons for Amyotrophic Lateral Sclerosis
Gerson Chadi, University of São Paulo, Brazil
10.30 – 11.00 Mini-brains to better understand schizophrenia and bipolar disorder
Daniel Martins-de-Souza, UNICAMP, Brazil
11.00 – 11.30 Coffee break
11.30 – 12.00 iPS for studying glucocerebrosidase: Implications for Parkinson and
Gaucher Diseases
Ellen Sidransky, National Institutes of Health, USA
12.00 – 13.30 Roundtable discussion: Toward a strategic science agenda for pathwaybased
human brain research in Brazil
Facilitators: Troy Seidle and Marcia Triunfol
13.30 – 13.40 Wrap-up
13.40 Close of meeting
Closing lunch