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BioMed21 – Emerging Technology Toward Pathway-Based Human Brain Research

29th and 30th of May, 2017

D’Or Institute, Rio de Janeiro, Brazil
Rua Diniz Cordeiro, 30
22281-100 – Botafogo-RJ

Hotel for guests and speakers
22061010 – RIO DE JANEIRO

Vegetarian meals
Xavier da Silveira, 28 – Copacabana, Rio de Janeiro – RJ, 22061-010, Brazil

On-site Buffet Service

International Airport in Rio de Janeiro

Domestic airport in Rio de Janeiro

Info about the meeting
The scientific concept that a given complex living organism may work as a model for the study of another of a different species has been challenged by an increasing number of scientists, who have exposed the many pitfalls of using animal models for studying human biology and human diseases. Fortunately, a range of advanced, human-based research models have emerged as a powerful alternative for biomedical research.

With this in mind, Humane Society International (HSI) has teamed up with the D’Or Institute for Research and Education (IDOR), to organize a 2-day scientific meeting entitled “BioMed21: Emerging Technology Toward Human Pathway-Based Brain Research.” The meeting will take place at the IDOR campus in Rio de Janeiro, Brazil on the 29th and 30th of May of 2017, and aims to foster strategic scientific dialogue regarding the need for an improved understanding of the pathophysiological mechanisms at the root of human brain diseases, and opportunities for wider application of mini-brains, iPSCs and related human-based models in brain research. A draft agenda for this working meeting is attached for your consideration.

This will be an in-depth, invitation-only working meeting, open to leading Brazilian and international scientists, funding agencies and investors, policy makers, and individuals working in regulatory agencies to discuss the potentials of this technology as a viable, safe, powerful and cost-effective alternative to failing animal models.

Monday, 29 May 2017

12.00 – 13.30
Welcome lunch

13.30 – 13.40
Welcome by Marcia Triunfol (HSI Brazil Science Advisor)

13.40 – 14.00
Toward a human pathway paradigm in health research
Troy Seidle, HSI Director of Research & Toxicology

14.00 – 14.30
Organoids: A historical perspective of thinking in three dimensions
Marina Simian, Instituto de Nanosistemas, Universidad Nacional de San
Martín, Argentina

14.30 – 15.00
New insights about the biology of zika virus infection using iPS cells
Stevens Rehen, D’Or Institute for Research and Education and Federal
University of Rio de Janeiro, Brazil

15.00 – 15.30
Mini-brains to study Dravet disease
Fabio Klamt, Universidade Federal do Rio Grande do Sul, Brazil

15.30 – 16.00
Coffee break

16.00 – 16.30
A human brain microphysiological system derived from iPSC to study
neurological diseases, toxicity and infection diseases
David Pamies, Johns Hopkins University, USA

16.30 – 17.00
Modeling autism spectrum disorders with human neurons
Patricia Beltrão-Braga, University of São Paulo, Brazil

Cocktail / Dinner (time and place to be announced)

Tuesday, 30 May 2017
09.00 – 09.30

09.30 – 10.00
The promises and challenges of human brain organoids as models of
neuropsychiatric diseases
Georgia Quadrato, Harvard Stem Cell Institute, USA

10.00 – 10.30
Human iPS-derived motor neurons for Amyotrophic Lateral Sclerosis
Gerson Chadi, University of São Paulo, Brazil

10.30 – 11.00
Combining neuroproteomics and mini-brains to understand psychiatric
Daniel Martins-de-Souza, University of Campinas, Brazil

11.00 – 11.30
Coffee break

11.30 – 12.00
Understanding Parkinson and Alzheimer diseases using patient neurons
derived from induced pluripotent stem cells (iPSC) coupled with analytic
biochemical techniques
Joseph R Mazzulli, Northwestern University Feinberg School of
Medicine, USA

12.00 – 13.30
Roundtable discussion: Toward a strategic science agenda for pathwaybased
human brain research in Brazil
Facilitators: Troy Seidle and Marcia Triunfol

13.30 – 13.40

Close of meeting

Closing lunch

Download the program flyer (PDF file) >>