Stem cells grown from human skin used to study fatty liver disease

Fatty liver disease affects hundreds of millions of people worldwide, but studying animals in the lab does not allow us to fully understand this uniquely human disease. Could using stem cells grown from human skin lead to better treatments? A team of innovative researchers at Vrije Universiteit in Brussels – led by Dr. Robim Rodriguez and Professor Tamara Vanhaecke – aims to find out.

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Move over monkeys: Understanding viral infections without using animals

Mosquito-borne viruses such as Zika and dengue are often studied using monkeys, mice and other animals, even though vaccines shown to protect monkeys from infection often don’t work in people. But is using animals really the most effective way to unlock the secrets to successfully preventing, treating—and even curing—these viral diseases? Find out what Dr. David Pamies at the University of Lausanne (formerly of the Johns Hopkins Center for Alternatives to Animal Testing)—along with his colleagues at Johns Hopkins University and the National Institute of Allergy and Infectious Diseases’ Vaccines Research Center in the U.S.—are doing to upend the status quo. Learn more »

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Early-career scientists awarded HTPC travel grants to attend JRC summer school on non-animal approaches

We are thrilled to announce financial support enabling three promising early career researchers to attend the European Commission’s Joint Research Centre (JRC) Summer School May 21-24 in Ispra, Italy, a week-long learning opportunity dedicated to non-animal approaches. These researchers have already shown impressive levels of dedication to the replacement of animals in their scientific careers so far and we are delighted to help further their education and training in innovative new technologies that do not rely on animals.

The summer school is a popular annual event for post-graduate researchers and early career researchers active in the fields of biomedical science and toxicology who are interested in learning about the latest advances in non-animal methods and technologies from experts in the field. Activities include debates, interactive sessions, poster presentations, and a visit to the EURL-ECVAM laboratories. The travel awards will help cover flight and accommodation costs for the researchers.

Nathalia Indolfo
São Paulo, Brazil

Nathalia actively developed and implemented non-animal approaches in her post at the Brazilian Biosciences National Laboratory (LNBio), where she was part of a project implementing OECD guidelines for the assessment of eye irritation and eye corrosion potential of chemicals using alternative methods.

Nathalia currently works at Natura, a Brazilian cosmetic company, where she is applying her knowledge and experience in non-animal methods as a product safety analyst.

Guilio Bracialente
Turin, Italy

Guilio is a chemical risk assessor and environmental consultant with extensive experience in assessing the potential risks posed by chemicals to human and environmental health. He has a particular interest in the risks and implications for health and the environment associated with products containing nanomaterials.

Giulio hopes that the summer school will provide him with a better understanding of in vitro and in silico non-animal methods that will be indispensable for his work in the regulatory arena.

Rohit Bhatia
Delhi, India

Rohit is an independent consultant focused on promoting the use of non-animal methods in research and testing. His background lies in chemistry and he has a proven track record of promoting the adoption of non-animal testing methods.

Rohit anticipates that attendance at the summer school will provide an exceptional opportunity to enhance his knowledge and learn from the best practitioners and experts in this area. He hopes that the knowledge and experience gained from the summer school will help achieve his objective of creating awareness and promoting the use of non-animal testing methods.

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SOT breakfast meeting on global collaboration for non-animal safety assessment

Please join Humane Society International at the Society of Toxicology’s annual meeting for a breakfast session focused on global collaboration for non-animal safety assessment. Breakfast is included.

Tuesday, March 12
6:30 AM–8:00 AM
Hilton Baltimore
Room: Peale A-C
401 West Pratt St, Baltimore, MD


Overview

There has been significant progress globally over recent years in advancing the science to underpin non-animal cosmetic safety assessment.  This has facilitated legislative change within some countries; however, to achieve a global ban on the use of animals in cosmetic safety assessment there is still more to do. Today we are announcing the launch of a collaboration between Humane Society International (HSI), industry partners, and other interested groups to help shape future cosmetics legislation and share the decision-making approaches which are being applied to assess safety without animals. The associated investment in education and training will ensure that there is the ongoing ability to meet regulations which require non-animal safety approaches.

In this interactive session, we will share the overall objectives of this collaboration and highlight opportunities to join, present examples of non-animal safety approaches, and discuss priorities for education and training. Join us find out more and/or share your thoughts.

 Agenda

6:30     Welcome & introduction – Catherine Willett, Humane Society International

6:50     ICCR framework & NGRA case study- Paul Carmichael and Gavin Maxwell, Unilever

7:10     Cheminformatics and toxicogenomics to support toxicity assessment – George Daston, Procter & Gamble

7:30     Round Table – Priorities for education & training*

7:50     Audience input – Voting on Education & Training (mentimeter)

*Round table participants:

  • Rebecca Clewell, Principal Consultant, 21st Century Tox Consulting, LLC
  • Chris Barber, CEO, Lhasa
  • Jay Ansell, PCPC Vice President Cosmetics Programs
  • Warren Casey, Director of the U.S. National Toxicology Program’s Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), National Institutes of Environmental Health Sciences (NIEHS)

Learn more about the collaboration » 

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Join us at our SOT satellite meeting for the latest updates on 21st century toxicology

Attending the the Society of Toxicology’s annual meeting this March? Join the Human Toxicology Project Consortium (HTPC) and the Center for Alternatives to Animal Testing (CAAT) at our annual satellite meeting on advancing 21st century toxicology activities. The meeting provides an informal setting for interested stakeholders to update one other on this important topic. A number of invited presentations are featured; there will also be time for an “open microphone” segment in which participants are welcome to make announcements or to comment on germane topics, with or without a few slides.

Updates on Activities Related to 21st Century Toxicology:
Invited Presentations and Open Microphone
Thursday, March 14, 2019, 12:30-4:00 pm
Hilton Baltimore Hotel, Baltimore, MD

Registration

Please register by email at your earliest convenience with Camila Januario at cjanuar1@jhu.edu. Box lunches will be available to those who have pre-registered.

Agenda

12:30  Welcome – Martin Stephens (Johns Hopkins University); Box lunch (for pre-registered participants)

1:00    Invited updates (10-minute talks each followed by up to 5 minutes of discussion)

  • ToxCast – Russell Thomas (EPA)
  • Tox21 – Rick Paules (NIEHS)
  • EU Tox-Risk – Bob van de Water (Leiden University)
  • ICCVAM – Nicole Kleinstreuer (NICEATM)
  • Organ-on-a-chip & Predictive Toxicology Roadmap – Suzanne Fitzpatrick (FDA)
  • Progress in implementing NAMs under TSCA – Gino Scarano (EPA)
  • Canadian Centre for Alternatives to Animal Methods – Charu Chandrasekera (University of Windsor)
  • Evidence-based data analytics predict human DILI using ToxCast data – Katya Tsaioun (Johns Hopkins)
  • Human Toxicology Project Consortium – Catherine Willett (Humane Society International)
  • CAAT’s In Silico Prediction Tool – Thomas Hartung (Johns Hopkins)

3:30    Open microphone for comments, announcements, and discussion

4:00    Adjourn

CAAT HTPC partners organs-on-chips Tox21 ToxCast

Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment

The next workshop in the “Beyond Science and Decisions” series, “Beyond Science and Decisions: From Problem Formulation to Dose-Response Assessment,” will take place February 26 and 27, 2019, at the offices of Texas Commission on Environmental Quality in Austin, Texas. The “Beyond Science and Decisions” workshop series continues and expands upon the discussion set forth by Science and Decisions: Advancement of Risk Assessment (NAS, 2009).

The workshop agenda can be found here: https://tera.org/Alliance%20for%20Risk/TCE2018/Beyond_Science2018_Agenda.pdf. The agenda will include several case studies and multiple talks across a variety of topics.

Registration is free and can be found at: https://tera.org/Alliance%20for%20Risk/Workshop/WS10Registration.html. A block of hotel rooms is being reserved at the HILTON GARDEN INN AUSTIN NORTH. Information about these accommodations will be on the registration website shortly.

Meetings & Events

Symposium to discuss global harmonization of vaccine testing requirements

Human Toxicology Project Consortium partner Humane Society International will present a Global Harmonization of Vaccine Testing symposium on March 19, 2019, in Rome. This event will bring together experts to discuss the elimination of abnormal toxicity tests and target animal batch safety tests for batch release of biologicals and immunologicals for human and veterinary use, a milestone that has been achieved in some regions. A key goal of the symposium is to explore barriers faced in regions still using these tests and what kind of actions should be taken or suggested to achieve elimination of these tests worldwide.

View a detailed overview of the symposium >>

For more information, contact Laura Viviani at lviviani@hsi.org.

HSI HTPC partners vaccine testing