OECD Calls for assays for Non-Genotoxic Carcinogens

The Organization for Economic Cooperation and Development (OECD) is looking for assays that could be used within the context of an Integrated Approach to Testing and Assessment to assess a chemicals potential for non-genotoxic carcinogenicity assessment. If you have or are developing such an assay, please let OECD know about it before June 15, 2018.

Please see the explanatory note and Excel assay collection template for reporting information about the assays to OECD.

Send all information to Nathalie.delrue@oecd.org by Friday 15 June 2018.

 

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Our new video is live – the third in our Pathways to a Better Future series!

We are excited to share our latest video with you! Human-Based Biological Pathways: Where does the information come from? is the third video in Pathways to a Better Future, a video series about new uses of science to avoid animal testing of chemicals and better protect ourselves and our environment. View the complete series of videos on our website or our YouTube channel.

 

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Gain hands-on experience with the AOP wiki at SOT’s annual meeting

Headed to the Society of Toxicology’s upcoming meeting in San Antonio? The Human Toxicology Project Consortium and the Physicians Committee for Responsible Medicine invite you to deepen your understanding of the AOP Wiki and gain experience entering an Adverse Outcome Pathway in a structured, hands-on seminar Tuesday evening.

Version 2.2 of the AOP Wiki was released in January 2018.  This seminar will be ideal for those wishing to gain some hands-on experience with the new version as well as those who are new to the AOP concept. We will also present an available online course on AOPs, and course attendees will work through a case example in small groups.

What: Hands-On Seminar: Creating an Adverse Outcome Pathway in the AOP Wiki
Where: Grand Hyatt, Rooms Bowie A – B, 600 E Market Street, San Antonio
When: Tuesday, March 13, 5:00 PM – 7:00 PM
Registration: Please register in advance by contacting Kristie Sullivan at ksullivan@pcrm.org. Registration is appreciated, but not required. Please indicate whether you will bring a laptop.

Agenda

5:00 – 5:20  Introduction to AOP concepts and online course
Catherine Willett, HTPC; Kristie Sullivan, PCRM

5:20 – 5:40  Creating and Using an AOP
Brigitte Landesmann, European Commission Joint Research Centre

5:40 – 6:00  Evaluating AOP Evidence
Bette Meek, University of Ottowa

6:00 – 7:00 AOP Wiki demonstration and hands-on activity
Dan Villeneuve, US EPA, with assistance from Kristie Sullivan, PCRM

AOP tutorials AOPs

World first as UK researchers infect artificial liver with Hepatitis B virus

Excerpted from The Engineer:

Researchers at Imperial College London have become the first in the world to test how pathogens interact with artificial human organs, so called organ-on-chip technologies. The group claims that the pioneering tests pave the way for an improved understanding and of a range of diseases enabling the development of new treatments. Keep reading »

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HTPC/HSUS awarded international Lush Prize in recognition of efforts to end animal testing

We’re proud to announce that we are the recipients of the prestigious Lush Prize award for training in recognition of our efforts to replace animal testing with alternatives.

The prize was awarded to the Human Toxicology Project Consortium (HTPC), in recognition of a training program we developed that helps scientists apply alternative methods. Lush created a video explaining the project.

The HTPC is a coalition of corporate and non-profit organizations, founded and coordinated by The Humane Society of the United States (HSUS) that promotes the development & implementation of non-animal science to improve chemical safety tests. As part of our training program, earlier this year we created a course to promote the concept and application of Adverse Outcome Pathways, or AOPs. An AOP is a flexible framework that describes the events that occur following chemical exposure. The course trains scientists to use a software package that allows them to organize and combine biological information. When organized this way, the information helps scientists predict what will happen after chemical exposure, as an alternative to testing that chemical on animals. The course was developed by the HTPC and etioLogic Consulting Services, in collaboration with an international group of scientists, and has been incorporated into the training materials of the Organisation for Economic Co-operation and Development (OECD).

Dr. Catherine Willett, Director of Regulatory Toxicology, Risk Assessment and Alternatives for The HSUS will accept the award at a ceremony in London this evening.

Lush Prize is a joint project between Lush Cosmetics and the Ethical Consumer Research Association (ECRA) and was founded in 2012 as a way of supporting initiatives to replace the use of animals in research. Prizes are awarded annually in Lobbying, Public Awareness, Science, Training, and Young Researchers, and each winner is awarded £50,000 (around $65,000). This year, more than 66 entries from 29 countries were submitted.

The prize money we receive will be used to continue our work to advance non-animal methods in research and testing.

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Species Extrapolation Workgroup at SETAC’s Annual Meeting

Planning to be in Minneapolis next week for the Society of Environmental Toxicology and Chemistry (SETAC) North America Annual Meeting? Please join us at The Species Extrapolation Workgroup, a meeting that will explore how scientists can protect endangered species while reducing animal testing.

Currently, data used to protect endangered species has the unintended consequence of helping to increase animal testing and prohibiting the acceptance of alternative test methods and data sources that would reduce or replace animal testing. Presentations and a discussion will explore what data is needed to protect endangered species and how improving species extrapolation methods could best address those needs.

The workgroup will be held on Sunday, November 12 from 1-4pm at the Minneapolis Convention Center, Room: M101J.

Register: http://www.setac.org/store/view_product.asp?id=9684852

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Emory University symposium to highlight animal-free innovations in biomedical research

Calling all Atlanta-area residents! The Human Toxicology Project Consortium, in collaboration with Emory University School of Law, will present a free half-day symposium on Monday, October 23rd, 2017 to showcase the latest animal-free innovations in biomedical research. These research methods and technologies offer the most efficient approach to pre-clinical drug and device development and toxicity testing of commercial chemicals.

Scientists, lawyers, students, other members of the Emory community and beyond are invited to hear about bio-technology, computer science and engineering approaches, such as sophisticated 3-D cell culture systems; stem cell technologies that allow research on individual diseases; organ-on-a-chip technologies; genomics; proteomics; metabolomics; computational modeling; bioinformatics “knowledge-bases”; and other platforms for linking mechanistic biological information and developing predictive models of human diseases.

The regulatory challenges of applying these technologies to drug and device development and toxicity testing will also be addressed. Presentations will be followed by a panel discussion and question and answer period with the audience.

The symposium is free to attend, but registration is required. Those who would like to participate in the free lunch following the symposium must register no later than Saturday, October 18th.

For more information and to register, please visit https://www.eventbrite.com/e/a-symposium-exploring-new-technologies-in-biomedical-research-tickets-37999430319.

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