On Sunday, August 24 – just ahead of the 9th World Congress on Alternatives and Animal Use in the Life Sciences (“WC9″) in Prague – the HTPC and Physicians Committee for Responsible Medicine (PCRM) co-sponsored an “AOPs 101” session. Like the sessions offered at SOT earlier this year, this one was designed to introduce the Adverse Outcome Pathway concept to scientists who want to learn more about it, including how to apply it in their own work.
The session opened with an overview and introduction by Catherine Willett (HTPC). Anne Gourmelon presented on the OECD’s AOP program. Kristie Sullivan (PCRM) gave an introduction to the AOP Wiki, and Hristo Aladjov (OECD) introduced Effectopedia. These overview talks were followed by two case study presentations: Joanna Jaworska (Procter & Gamble) described the use of AOPs in a Bayesian network ITS framework to assess skin sensitization, and Nicole Kleinstreuer (ILS, Inc./NICEATM) described the construction of AOPs for developmental toxicities. The talks generated excellent follow-up questions and discussion.