Sleepless in Seattle: An update from the World Congress on Alternatives and Animal Use in the Life Sciences

Our experts will be working round-the-clock in Seattle this week at the World Congress on Alternatives and Animal Use in the Life Sciences! Over the next several days, staff from The Humane Society of the United States, Humane Society International & The Humane Society Legislative Fund will be at the vanguard of the discussion at this global event that brings together the world’s foremost experts on animal testing alternatives & animal welfare from industry, government, non-profits & academia.

Are you in Seattle, too? Please visit us at our booth (#309) and plan to attend the following events! Somewhere else in the world? Check out what we’re up to below and view the World Congress program.

SUNDAY, AUGUST 20

• 10:00 a.m. – noon
“Introduction to Adverse Outcome Pathways and the AOP Wiki” Satellite Meeting
Sheraton Seattle, Aspen Room
10:00 a.m. Introduction to the OECD AOP Programme and Online Training course – Kate Willett, Human Toxicology Project Council
10:40 a.m. Building AOPs for Neurotoxicity: Perspective from an Academic – Ellen Fritsche, IUF – Leibniz Research Institute for Environmental Medicine
11:20 a.m. Demonstration and Hands-On Activity with AOP Wiki – Kristie Sullivan, Physicians Committee for Responsibility MedicineSponsors: Human Toxicology Project Consortium and the Physicians Committee for Responsible Medicine

MONDAY, AUGUST 21

• 12:15 p.m. – 1:15 p.m.
“Tracking the successful implementation of Tox21 principles.”
Room 6ABC, Board number A43
Poster presenter Vicki Katrinak looks at how the chemical safety testing landscape has changed over the past ten years, as toxicologists embrace new, non-animal testing strategies.

• 12:15 p.m. – 1:15 p.m.
“Legislative process toward animal testing bans for cosmetics in Brazil.”
Room 6ABC, Board number A44
Poster presenter Antoniana Ottoni discusses how the Brazilian authorities aim to implement validated alternative, non-animal tests for commonly used toxicological endpoints and reviews plans to ensure the regulations are updated before the deadline of 2019.

• 2:00 p.m.
“Implications of the Recent 2016 Amendment of the Toxic Substances Control Act (TSCA) on the Development and Implementation of Non-Animal Methods.”
Session II-2: Government Driven Legislation – EDSP/TSCA; 1:15 p.m. – 2:45 p.m.; Rooms 613-614
Speaker Catherine Willett will explain how animal testing could actually increase under the new chemical safety act, and describe how co-ordinated efforts are needed to exploit non-vertebrate models and other evaluation tools to prevent this.

TUESDAY, AUGUST 22

• 10:30 a.m.
“Challenges in implementing the Frank R. Lautenberg Chemical Safety for the 21st Century Act: A perspective covering stakeholders, the U.S. Congress and the current Administration.”
Session IX-4: Global Regulatory Updates; 10:00 a.m. – noon; Room 607
Speaker: Sara Amundson

• 12:15 p.m. – 1:15 p.m.
“Modeling the human airways: from physiology to pathology.”
Room 6ABC, Board number A65
Poster presenter Lindsay Marshall shows how laboratory models using human cells can be used to look at the function of healthy airways and demonstrates that the models can be adapted to enable the study of airways disease, such as cystic fibrosis.

• 12:15 p.m. – 1:15 p.m.
“iPSC and 3D tissue technologies powerful alternatives to animal models for brain disease research”
Room 6ABC, Board number A77
Poster presenter Marcia Triunfol reports on an exciting, HSI-sponsored workshop held in Brazil earlier this year. Brazilian and international scientists discussed the potential for 21st century technologies to replace animals in brain research.

WEDNESDAY, AUGUST 23

• 12:15 p.m. – 1:00 p.m.
“A ‘bottom-up’ approach to accelerate new opportunities in alternatives and Adverse Outcome Pathway (AOP) practice in China”
Room 6ABC, Board number C81
Poster presenter Tina Qu reports on the progress made in promoting non-animal technologies in China, including the recent roll-out of an AOP-training program.

• 10:45 a.m.
“Towards a 21st-century roadmap for biomedical research and drug discovery”
Session IX-8: Global Efforts Moving Towards Replacement of Animals;
10:00 a.m. – noon; Rooms 619-620
Speaker Troy Seidle describes the application of pathways-based approaches to understand chemical safety and details how a series of workshops sponsored by The Humane Society of the United States and Humane Society International have introduced this concept to other stakeholders – describing the main recommendations from these events.

THURSDAY, AUGUST 24

• 10:48 a.m.
“The Human Toxicology Project Consortium: a private-public partnership to promote development and acceptance of pathway-based science”
Session IX-6: 3Rs Communication and Advocacy; 10:00 a.m. – noon; Rooms 619-620
Speaker Catherine Willett will describe the work of the Human Toxicology Project Consortium (HTPC), which aims to advance a biological pathway-based approach to toxicology. She will explain how HTPC intends to achieve this through scientific activities, communication, and advocating for financial and legislative support.

• 11:45 a.m.
“Deletion of scientifically redundant animal test requirements in the agrochemical sector: the case of the 1-year dog study”
Session IV-1: Predictive Safety Approaches Role in the Design of Inherently Safer Chemicals; 10:00 a.m. – noon; Rooms 615-616
Speaker Marco Corvaro will explain how the ongoing global effort to end a test that has been proven redundant illustrates how challenging it can be to enact regulatory change. He will also discuss strategies to improve the use of modern approaches to testing and risk assessment.

• 11:46 a.m.
“A campaign to end invasive chimpanzee research and retire all chimpanzees to sanctuaries: successful strategies and lessons learned”
Session IX-6: 3Rs Communication and Advocacy; 10:00 a.m. – noon; Rooms 619-620
Speaker Kathleen Conlee will take us from 2006, when The Humane Society of the United States launched their campaign to end the use of chimpanzees in invasive research, to today where numbers of chimps in labs have dropped and research chimps are finally being retired to sanctuaries.

AOP tutorials AOPs non-animal tests toxicity testing alternatives toxicology World Congress on Alternatives
Picture of video reel, by Coyau / Wikimedia Commons / CC-BY-SA-3.0